Electrochemical DNA detection

Invented by scientists from the Laboratoire d’Électrochimie Moléculaire (LEM-Université Paris Diderot), Damien Marchal and Benoit Limoges, DetScan™ is protected by several patents. Based on electrochemistry, it allows a non-optical and parallelised detection of biological molecules (DNA, RNA and proteins).

As many approaches in the biosensor field, DetScan™ technology has the particularity to gather all the advantages of the electronic industry in terms of robustness, cost and miniaturization potential.

Principle of DetScan™

DetScan™ technology is based on a measurement of the interaction between an electrochemical binding probe and a biological molecule.

Technology Principle

Technology Principle
DetScan™ uses a similar principle to that conventionally used in optical applications: the interaction of a compound, in this case electrically active, with biological molecules.


DetScan™ could be considered as a generic technology which allows the development of several applications in detection, analysis and quantification of a biological molecule in a sample.

DetScan™ technology was for the first time described in 2006 for a non-optical real-time PCR experiment using cyclic voltammetry. Since this proof of principle, it has been optimised and adapted to several and daily used applications in molecular biology.

Electrochemical Real-Time PCR experiments

DetScan™ electrochemical DNA detection offers SYBR Green similar sensitivity.

Electrochemical melt curves

DetScan™ electrochemical DNA detection allows melting curves experiments.
Electrophoresis gels are no longer necessary.

Genotyping experiment

Electrochemical DNA detection allows genotyping analysis.

Isothermal amplification experiment

DetScan™ electrochemical DNA detection allows to monitor electrochemically
and in real time an isothermal HDA amplification.

Expand beyond boundaries

  • Electrochemistry used for biological molecules detection is an open gate to new applications.
  • Robustness, miniaturization and low cost procedures are key criteria favoured by new players such as the Diagnostic and the Agro-food industries.
  • In the PCR field, DetScan™ and Leo will lure new users to PCR.


Real-Time Electrochemical Monitoring of Isothermal Helicase-Dependent Amplification of Nucleic Acids, F. Kivlehan, F. Mavré, L. Talini, B. Limoges, D. Marchal. Analyst, 2011, 136, 3635-3642

Real-Time Electrochemical PCR with a DNA Intercalating Redox Probe, T. Deféver, M. Druet, D. Evrard, D. Marchal, B. Limoges.
Anal. Chem., 2011 83 (5), 1815-1821

Real-Time Electrochemical Monitoring of the Polymerase Chain Reaction by Mediated Redox Catalysis, T. Deféver, M. Druet, M. Rochelet-Dequaire, M. Joannes, C. Grossiord, B. Limoges, D. Marchal.
J. Am. Chem. Soc., 2009, 131 (32), 11433–11441

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