As many approaches in the biosensor field, DetScan™ technology has the particularity to gather all the advantages of the electronic industry in terms of robustness, cost and miniaturization potential.
DetScan™ technology is based on a measurement of the interaction between an electrochemical binding probe and a biological molecule.
DetScan™ could be considered as a generic technology which allows the development of several applications in detection, analysis and quantification of a biological molecule in a sample.
DetScan™ technology was for the first time described in 2006 for a non-optical real-time PCR experiment using cyclic voltammetry. Since this proof of principle, it has been optimised and adapted to several and daily used applications in molecular biology.
Real-Time Electrochemical Monitoring of Isothermal Helicase-Dependent Amplification of Nucleic Acids, F. Kivlehan, F. Mavré, L. Talini, B. Limoges, D. Marchal. Analyst, 2011, 136, 3635-3642
Real-Time Electrochemical PCR with a DNA Intercalating Redox Probe, T. Deféver, M. Druet, D. Evrard, D. Marchal, B. Limoges.
Anal. Chem., 2011 83 (5), 1815-1821
Real-Time Electrochemical Monitoring of the Polymerase Chain Reaction by Mediated Redox Catalysis, T. Deféver, M. Druet, M. Rochelet-Dequaire, M. Joannes, C. Grossiord, B. Limoges, D. Marchal.
J. Am. Chem. Soc., 2009, 131 (32), 11433–11441
an electronic based technology